A Research Article Digest: A Conclusive Example of Evolutionarily Relevant Biological Role for G-Quadruplex Structural Motif in LINE-1 Elements
Journal: Nature Str. Mol. Biol., 2017, aop.
Simple Short Explanation of the Work for Everyone:
Approximately half of our genome is originated from mobile DNA elements, which are DNA segments that insert themselves at different positions in a “host” genome they infiltrate. Some mobile DNA elements increase their genomic copy numbers via a copy-and-paste mechanism, extending the length of our genome in an evolutionary timescale. In this study, we present an evidence that a specific guanine(G)-reach region in LINE-1 retrotransposons, type of mobile DNA elements that played a significant role in shaping mammalian genome architecture, has functional role in LINE-1 mobility. By a thorough dusting of the low-complexity G-rich regions in ancient LINE-1 remnants, dead at different time epochs, we revealed the original G-rich sequences prese…